autoimmune disease, which is the most common cause of Addison’s disease, according to the National Institute of Diabetes and Digestive and Kidney Diseases.There are many potential causes of adrenal insufficiency, including: This means that the adrenals cannot make enough cortisol. Without CRH, the pituitary gland cannot make ACTH. This occurs when the brain cannot produce enough corticotropin-releasing hormone (CRH). Without ACTH, the adrenals do not receive a signal to make cortisol. This occurs when the pituitary gland does not make enough of a hormone called adrenocorticotropin (ACTH). This condition develops when the adrenal gland itself does not function well and cannot make enough cortisol.
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